Objective: To understand the current status of death literacy among secondary vocational students, and analyze its influencing factors, providing a reference for school administrators to formulate intervention measures aimed at enhancing the level of death literacy of secondary vocational students. Methods: Convenience sampling was used to investigate 712 secondary vocational students in a technical school in Guangzhou, utilizing a general information questionnaire, Death Literacy Index and a Chinese Meaning of Life Questionnaire. Results: The score of students’ death literacy in secondary vocational schools was 5.63±2.22 points. The results of multiple linear regression analysis showed that gender, whether the major is medical-related, living situation, and sense of meaning in life are influencing factors of life and death literacy among secondary vocational schools (P<0.01). Conclusion: The death literacy of secondary vocational students is at a medium level. School leaders can provide targeted death education for students of different genders, various majors, and those who live with non-parents, and can? enhance the death literacy of secondary vocational students by helping them find the meaning in life.