In contrast to elderly patients, young patients often play central roles within their families. Consequently, they undergo profound spiritual distress in the late stages of life, yearning for emotional sustenance or seeking liberation in their relationships with self and others. Through clinical cases, we have preliminarily observed that patients engaged in nurturing intimate relationships primarily express spiritual needs for emotional support. Family members’ support and companionship, along with community resources, play a vital role. Clinical care and companionship should emphasize respect, support, and tailored spiritual care to meet patients’ needs for spiritual growth. Conversely, patients lacking family support in consumptive intimate relationships may turn to transcendence or religion for solace. They require increased companionship from palliative care and hospice teams and clinical spiritual care chaplains to gain strength and alleviate anxiety. In conclusion, clinical spiritual care chaplains should prioritize patients’ spiritual pain and need for spiritual growth, aiding in life review, reconstructing the meaning of life, self-discovery, connecting with their origins, and seeking relief or transcendence, ultimately fostering a sense of peace.